Potassium Channel

KcsA

Potassium Channel

Related Products

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (881)
Antibodies (6)
Related Compound Screening Libraries (1)

By Effects:	Controls (9) Inhibitors (540) Agonists (14) Antagonists (35) Activators (180) Modulators (30) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W013175

Uridine 5'-monophosphate disodium salt	Activator	99.90%
Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.

HY-157557

AP30663	Inhibitor	99.99%
AP30663 is a KCa2 channel inhibitor that can be used for the study of atrial fibrillation.

HY-120348

ML67-33	Activator	99.28%
ML67-33 is a selective activator of temperature- and mechano-sensitive K_2P channels. ML67-33 rapidly and reversibly affects K_2P2.1 (TREK-1) with EC₅₀s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively.

HY-B0267

Oxybutynin	Inhibitor	99.86%
Oxybutynin is an anticholinergic agent, which inhibits vascular K_v channels in a concentration-dependent manner, with an IC₅₀ of 11.51 μM. Oxybutynin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0387

Ibutilide fumarate	Inhibitor	99.78%
Ibutilide (U70226E) fumarate, an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K⁺ current (I_Kr) in AT-1 cells.

HY-108593

BMS-191011	Activator	99.12%
BMS 191011 (BMS-A) is a potent BK_Ca channel opener (large-conductance Ca²⁺-activated potassium channel). BMS-191011 shows neuroprotective activities in rodent models of stroke.

HY-W011509

CyPPA	Activator	99.98%
CyPPA is a positive modulator of hSK3 and hSK2, with EC₅₀ values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels^[1]

HY-B0920

Tolazamide		99.87%
Tolazamide (U-17835) is an orally active sulfonylurea agent that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (IC₅₀ = 4.2 µM in HEK293 cells transfected with the human receptor). Tolazamide has anti-diabetic properties. Tolazamide can lower blood glucose in sulfonylurea class. Tolazamide decreases insulin dose while continuing to maintain adequate metabolic control. Tolazamide is able to improve or normalize hyperglycemia and HbA.

HY-B1467

Domiphen bromide	Inhibitor	99.61%
Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC₅₀: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers.

HY-16738A

Eleclazine hydrochloride	Inhibitor	99.66%
Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC₅₀ value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine hydrochloride can be used to research cardiac arrhythmias.

HY-163387

CHI3L1-IN-1	Inhibitor	99.68%
CHI3L1-IN-1 (Compound 30) is an inhibitor for Chitinase-3-like protein 1 (CHI3L1) (YKL-40) with IC₅₀ of 50 nM. CHI3L1-IN-1 inhibits hERG channel with an IC₅₀ of 2.3 μM.

HY-111655

SKA-31	Activator	99.66%
SKA-31 is a potent potassium channel activator with EC_50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure.

HY-P0190

Iberiotoxin	Inhibitor	98.63%
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca²⁺-activated K⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels.

HY-100712

DPO-1	Inhibitor	98.39%
DPO-1 is a potent inhibitor of the voltage-gated potassium channel subtype K_v1.5 and a blocker of ultrarapid delayed rectifier potassium current. DPO-1 prevents atrial arrhythmia.

HY-14290A

Pinacidil monohydrate		99.92%
Pinacidil (P-1134) monohydrate is a potent activator of ATP-sensitive potassium channel. Pinacidil monohydrate is an antihypertensive agent hyperpolarizes vascular smooth muscle by opening K⁺ channels. Pinacidil monohydrate enhances K⁺-efflux in smooth muscle. Pinacidil monohydrate has vasorelaxant properties. Pinacidil monohydrate is able to inhibit spontaneous tone and of reducing agonist induced contractions. Pinacidil monohydrate can be studied in research area such as cardiovascular diseases.

HY-17437

Mefloquine	Antagonist	99.96%
Mefloquine (Mefloquin), an orally active and potent quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K⁺ channel (KvQT1/minK) antagonist with an IC₅₀ of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus and cancer research.

HY-B0563A

Ropivacaine hydrochloride monohydrate	Inhibitor	99.82%
Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane. Ropivacaine is widely used for regional anesthesia and neuropathic pain management in vivo.

HY-N0663

Talatisamine	Inhibitor	99.77%
Talatisamine, a aconitum alkaloid, is specific K⁺ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons.

HY-B2133

Cloperastine hydrochloride	Inhibitor	99.39%
Cloperastine hydrochloride inhibits the hERG K⁺ currents in a concentration-dependent manner with an IC₅₀ value of 27 nM.

HY-14183

Vernakalant Hydrochloride	Inhibitor	99.33%
Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na⁺ and atria-preferred K⁺ channel blocker. IC₅₀ for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channel^wt, Kv1.5 channel^I508F, Kv1.5 channel^T479A, respectively.

Potassium Channel Compound Library

Compound library containing a variety of potassium channel inhibitors and activators.

284compounds HY-L119

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (881)

Antibodies (6)

Related Compound Screening Libraries (1)

Potassium Channel Related Products (881):